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1996-03-09
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Document 0433
DOCN M9650433
TI Steps toward gene therapy: 1. The initial trials.
DT 9605
AU Blaese RM; Clinical Gene Therapy Branch, National Center for Human
Genome; Research, National Institutes of Health, Bethesda, Md., USA.
SO Hosp Pract (Off Ed). 1995 Nov 15;30(11):33-40. Unique Identifier :
AIDSLINE MED/96110745
AB Hopes for correcting the instruction tape in patients with genetic
disease are being intensively explored. Initial efforts centered on
monogenic immunodeficiency states, but in a pattern not wholly expected
by researchers, the acquired genetic diseases of cancer and AIDS account
for most ongoing clinical trials. Experience with adenosine deaminase
deficiency shows the difficulties encountered in creating practical gene
therapies.
DE Adenosine Deaminase/*DEFICIENCY Child, Preschool Gene Therapy/*METHODS
Genetic Engineering Genetic Vectors Human Moloney Leukemia Virus
Severe Combined Immunodeficiency/ENZYMOLOGY/GENETICS/*THERAPY JOURNAL
ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).